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Their use must be medically supervised due to risk of side effects and dependence. 1. Fentanyl One of the most potent opioids available; used in severe pain and anesthesia. Forms: patches, lozenges, injectables. 2. Hydromorphone (Dilaudid) Stronger than morphine; used in acute severe pain, including cancer pain. 3. Methadone Long-acting opioid used for pain and addiction treatment; complex dosing requires specialist oversight. 4. Oxycodone (OxyContin, Percocet) Commonly prescribed for moderate-to-severe pain; often combined with acetaminophen. 5. Morphine A classic opioid for severe pain, especially in hospital and palliative care settings. 6. Oxymorphone Stronger than oxycodone, used in severe pain management. 7. Hydrocodone (Vicodin, Norco) Widely used for moderate to severe pain; typically combined with acetaminophen. 8. Tapentadol (Nucynta) Opioid-like pain reliever with additional nerve-pain relief properties. 9. 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